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Taking drugs with a toxic effect, such as itraconazole (used to treat fungal diseases), methotrexate (antineoplastic drug), NSAIDs (painkillers: Analgin, Nurofen, Nimesulide, Nise, etc.) - they disrupt implantation processes due to inhibition of prostaglandin synthesis. Retinoids (teratogens), paroxetine and venflaxin (antidepressants with strong anti-anxiety effects) also have toxic effects.